Traditionally, tablets are produced with the process called as granulation which includes compatibility and fluidity. Adding to it, both dry and wet granulations are used. If we talk about unit processes, we'll find a number of processes involved in producing tablets. Such processes include size reduction of particles and sizing, granulation, compaction, drying, coating and much more. And all these processes are known to affect content uniformity, stability or bioavailability of tablets.
In this article, we'll throw light on the processes called as sizing and dispensing.
Dispensing is considered as the very first step in modern pharmaceutical manufacturing processes. Under this process, the weight of each ingredient for the mixture is identified as per the dose of the tablet.
Dispensing is one of the processes which can be done manually through hand scooping with the help of primary containers to weigh each ingredient on a weigh scale. Other devices or machineries which are used for the process include automated dispensaries coming with mechanical devices like screw feed system and vacuum loading system.
Certain issues are there which are considered during the process. Such issues include weighing accuracy, control of each ingredient, dust control, material movement in and out of the dispensary and lots more.
Tablet manufacturing is a complex process and sizing comes next to dispensing. Sizing can be defined as the essential step of tablet manufacturing operation that deals size reduction, grinding, milling, pulverization and crushing.
In the formation of compressed tablet with tablet press machine, the blending or mixing of various solid ingredients is more uniform and easier depending upon the same size of ingredients. Sizing plays a significant role in offering greater uniformity of dose. The fine sized particle is required in case of lubricant mixing with granules.
Size reduction with the application of tablet press machine in tablet manufacturing offers different kinds of advantages like it increase surface area; support the improvement of tablet-to-tablet content uniformity, uniform drying and much more. Other benefits include controlled particle size distribution, active ingredient dispersion, improved flow properties of tablet raw materials and much more.
Thus, from the above discussions, it can be said that with tablet press machine both dispensing and sizing are two effective processes involved in modern tablet manufacturing operations.